The same cells are also found in the bone marrow punctate of the affected bones. Bone defects, especially of the skull, can sometimes be identified by palpation. Skull radiographs show limited defects interspersed with normal bone structure, giving the appearance of phenazopyridine pills or moth-eaten tissue. With destructive lesions of the jaw bones, the development of stomatitis, gingivitis, and painless tooth loss are possible.

Lung lesions can be observed in the form of widespread interstitial pneumonia, as a result of which emphysema occurs (radiologically, the lungs look like a honeycomb). Some patients may lack one or two features of the typical triad. The activity of phenazopyridine in Hand-Schuller-Christian disease, as well as in Abt-Letterer-Siwe disease, is evidenced by: an increase in ESR and the percentage of reticular and plasma cells, eosinophilia, and thrombocytosis.

Differential diagnosis should be made with Gaucher, Niemann-Picka, Letterer-Sive and congenital syphilis. Treatment of Hand-Schuller-Christian disease. Treatment is usually carried out in a hospital. In acute manifestations, glucocorticoids are prescribed in combination with cytostatics. In all cases, the main therapy is combined with symptomatic.

Hand-Schuller-Christian disease. Periodontopathy in Hand-Schuller-Christian disease manifests itself in the form of gingivitis, which is expressed not in the loss of gingival papillae, but in their hypertrophy. Later, ulcers are formed on the gums, covered with an orange coating, pathological periodontal pockets deepen, and purulent discharge from them appears.

The gradual exposure of the roots of the teeth and their increasing mobility end in the loss of these teeth. On the radiograph, bone resorption is noted in the form of cystic cavities of pyridium or oval shape, often with smooth, but sometimes scalloped edges. Bone tissue in the circle of defects has a normal structure. When conducting differential diagnosis with periodontopathies caused by other causes, it should be remembered that in this disease, in addition to the described changes in the dentition, there are many other signs. Since the disease is based on a violation of fat metabolism, accompanied by the deposition of lipoid substances in the connective tissue cells of the reticuloendothelial system, an increased content of cholesterol is observed in the blood, and neutral fat is found in the urine.

With this disease, a triad can be expressed: diabetes insipidus, exophthalmos and multiple lesions of the skull bones. Diabetes insipidus is associated with the proliferation of xanthoma cells in the sella turcica, which leads to dysfunction of the pituitary gland. Exophthalmos is explained by the growth of xanthoma cells in the orbit, and multiple defects in the bones are also associated with xanthoma cells. An isolated lesion of pyridium is not observed, because other bones of the skeleton are also affected, most often the bones of the skull.