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The disease refers to disorders of lipid metabolism. It is assumed that reticulosis develops primarily, and secondarily, due to a violation of cell permeability, lipids are excessively deposited. Violation of cellular metabolism plays an important role.

The same cells are also found in the bone marrow punctate of the affected bones. Bone defects, especially of the skull, can sometimes be identified by palpation. Skull radiographs show limited defects interspersed with normal bone structure, giving the appearance of phenazopyridine pills or moth-eaten tissue. With destructive lesions of the jaw bones, the development of stomatitis, gingivitis, and painless tooth loss are possible.

Lung lesions can be observed in the form of widespread interstitial pneumonia, as a result of which emphysema occurs (radiologically, the lungs look like a honeycomb). Some patients may lack one or two features of the typical triad. The activity of phenazopyridine in Hand-Schuller-Christian disease, as well as in Abt-Letterer-Siwe disease, is evidenced by: an increase in ESR and the percentage of reticular and plasma cells, eosinophilia, and thrombocytosis.

Differential diagnosis should be made with Gaucher, Niemann-Picka, Letterer-Sive and congenital syphilis. Treatment of Hand-Schuller-Christian disease. Treatment is usually carried out in a hospital. In acute manifestations, glucocorticoids are prescribed in combination with cytostatics. In all cases, the main therapy is combined with symptomatic.

Hand-Schuller-Christian disease. Periodontopathy in Hand-Schuller-Christian disease manifests itself in the form of gingivitis, which is expressed not in the loss of gingival papillae, but in their hypertrophy. Later, ulcers are formed on the gums, covered with an orange coating, pathological periodontal pockets deepen, and purulent discharge from them appears.

The gradual exposure of the roots of the teeth and their increasing mobility end in the loss of these teeth. On the radiograph, bone resorption is noted in the form of cystic cavities of pyridium or oval shape, often with smooth, but sometimes scalloped edges. Bone tissue in the circle of defects has a normal structure. When conducting differential diagnosis with periodontopathies caused by other causes, it should be remembered that in this disease, in addition to the described changes in the dentition, there are many other signs. Since the disease is based on a violation of fat metabolism, accompanied by the deposition of lipoid substances in the connective tissue cells of the reticuloendothelial system, an increased content of cholesterol is observed in the blood, and neutral fat is found in the urine.

With this disease, a triad can be expressed: diabetes insipidus, exophthalmos and multiple lesions of the skull bones. Diabetes insipidus is associated with the proliferation of xanthoma cells in the sella turcica, which leads to dysfunction of the pituitary gland. Exophthalmos is explained by the growth of xanthoma cells in the orbit, and multiple defects in the bones are also associated with xanthoma cells. An isolated lesion of pyridium is not observed, because other bones of the skeleton are also affected, most often the bones of the skull.

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The decisive diagnostic sign is the detection of xanthoma cells in the punctures of the bone marrow of the sternum and in the spleen.

Secondary anemia, hemorrhagic rashes and hemorrhages under the skin are possible. The clinical picture of periodontal overload is varied and depends on the type of bite pathology. The most typical symptoms of periodontopathy caused by occlusion pathology are: inflammatory changes in the gingival mucosa, exposure of the necks of the teeth, atrophy of the bone tissue of the overloaded socket wall, in severe cases, displacement and mobility of individual teeth.

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The radiograph often reveals an expansion of the periodontal gap, atrophy of the interalveolar septa and overloaded walls of the holes

The endocrine system regulates and directs the main life processes of the child's body during its growth and development. In particular, the activity of the endocrine glands depends on the rate of ossification of the skeleton, including the dentition. Hypothyroidism (myxedema) is a common affliction in children and occurs as a result of decreased thyroid function. With this disease, insufficient development of the alveolar processes, some swelling of the gums are observed.

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Sporadic pituitary dwarfism is caused by hypofunction of the anterior pituitary gland.

It comes to light on the 3rd year of life of the child. Such dwarfs have a puppet appearance, normal intelligence. Most often, changes in the periodontium are found in the group of pyridium with dwarfism with delayed sexual development and with hypothyroidism. In children suffering from dwarfism at the age of 3 to 6 years, periodontopathic syndrome was not detected. It is generally accepted that the main lesion is located in the anterior pituitary gland and secondarily involved in the process of the adrenal cortex, sex glands and other parts of the endocrine system. In the epididymis of the brain with Itsenko-Cushing's disease, an intrasaddle tumor develops - a small adenoma of basophilic cellular elements that secrete a gonadotropic secret.

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Parasitization is fraught with the development of inflammatory-dystrophic and degenerative processes in the internal organs, leading to disruption of their functioning.
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Gradually, malaise develops, the child quickly gets tired, becomes irritable, his appetite decreases, up to anorexia, abdominal pain, nausea, and constipation appear. The most typical is the triad of signs: 1) multipledestructive changes in the bones of the skull, spine, pelvis, ribs, limbs; 2) exophthalmos; 3) diabetes insipidus. Patients can drink and excrete up to 10-12 liters of fluid per day. They vomit, lose body weight, up to complete exhaustion, growth slows down, and there is a lag in physical and mental development. Skin changes are noted in 1/3 of patients: dryness, follicular bright red, and then yellow, slightly scaly papules, petechial elements, hemorrhagic crusts, punctate scars. The picture is very similar to rashes in Abt-Letterer-Siwe disease. They have the same, but more limited localization, damage to the nail plates is also possible. Diagnosis of Hand-Schuller-Christian disease.